I think "Are you vegetarian" can be seen as either "Are you ethically or religiously opposed to eating meat" or "Is your normal diet meat free" where the latter (but not the former) can be answered "yes" by all the poor Mexicans who would be happy for you to buy them a steak.
However, I think if you asked: (A) "Did you eat meat in the past week" vs. (B) "Are you vegetarian", then broadly speaking, (A) will tend to gather higher numbers than (B) in low-income countries while (B) will tend to gather higher numbers in rich countries. So perhaps there's some kind of interaction between wealth (and wealth distribution) and survey methodology.
At least for Taiwan, I think a fair number of people are vegetarian for religious (Buddhism) reasons. And it's generally considered one of the more vegetarian-friendly places to visit. That said, my instinct is that the absolute numbers are on the high side for everywhere except perhaps India.
I can easily believe that there a million of Chinese who cannot afford meat and so are classed as vegetarian. I cannot believe that there are similar numbers of Chinese who don't eat meat for ethical reasons.
Brilliant breakdown of drug naming conventions. The hierarchical suffix system is way more structured than I expected, the PARP inhibitor example with poly ADP-ribose polymerase encoding directly into "parib" is particularly elegant. I've always found it fascinating how pharmaceutical nomenclature tries to balance systematic classification with pronounceability. One thing I noticed working in biotech tho is that these naming patterns sometimes create false associations where drugs with similar suffixes get mentally grouped even when their mechanisms differ significantly in practice.
Email spoofing is trivial. Anyone can send an email where the "From:" field says audit@irs.gov, compliance@bigbank.com, donations@localcharity.org or any other address, such as cheap_pills@dynomight.net. Very likely there has been spam spoofed from dynomight.net. Spammers spoof their emails from lots of random real domains. There are extensions to the SMTP protocol to address spoofing, but it's still a problem.
That's why SpamHaus will not believe you right away if you send an email to them where the address in your "From:" is the same tutanota.com address on the About page. Anyone can do that! You need to provide more proof. For example, SpamHaus might ask you to add a property to your dynomight.net DNS record.
That sounds reasonable, and I'd be happy to add a DNS record. But they don't offer any way to do that! After my first attempt my starting line was "I've tried this in the past and you keep closing my tickets with the same generic boilerplate, please tell me exactly what I need to do!" Then they repeat the exact same generic boilerplate and close the ticket, every time.
Unfortunately, SpamHaus has a reputation for exactly the sort of treatment you're getting. To be fair to them, they get huge numbers of SBL removal requests since they want to police the whole Internet, and many are actually maliciously deceptive requests from spammers.
I can only wish you good luck in getting to a human who actually cares about your problem, if the automated systems are barfing on you.
But honestly, if you're not planning on sending any email from dynomight.net, you might consider leaving it blocked to deny its use to actual spammers. In fact, the lack of legitimate emails from the domain is one factor that led to their algorithms blackballing you.
Oh yes, there are some ISPs that "helpfully" provide a service that blocks malicious websites based on SBL. Ouch. That's painful.
When you communicate with them, are you providing them an email address from tutanota.com, or dynomight.net? If possible, do the latter. You're talking to a rather stupid automated system that has very strict business rules to deal with floods of spammers trying to trick it.
You see, there *is* no email address at dynomight.net. There's no mail server attached, at all. I suppose I could set one up, but going to that much trouble just on a hunch which might or might not lead to a human response which might or might not get me unblocked for the zero spamming I've ever done kind of feels like a violation of my human dignity...
You'll need to check with your email provider and DNS registrar how to do this, but it's not very difficult. You don't have to build an entire email server. You just need to fiddle with some settings at your providers. A few hour project at most, where LLMs can generally give you accurate advice. It should be free, unless your providers are barbaric.
This is still absolute bullshit, I know. Consider it your blood offering to the Internet security gods? You get functioning email at dynomight.net as a bonus at the end? Otherwise you need to get a human at SpamHaus to pay attention.
Including the “Stem Book”, the formal list of all official drug name suffixes, prefixes, and infixes, as well as the “Pre-Stem List” of proposed stems and naming conventions not yet officially adopted.
This is much better than the horrible spreadsheet I found before! But it's not quite what I was hoping for since (1) There's no visualization. (2) It doesn't really explain the tree structure. For example, it doesn't seem to explicitly mention that "-ib" indicates a small molecule inhibitor, even though it surely does. (3) It doesn't explain where the names come from.
I tried this, but I had a hell of a time even getting it to generate that "-vir" subtree. In order to do that I had to correct lots of mistakes and constantly remind it to follow the exact format I specified, rather than sort or regurgitating the format in existing lists of suffixes. But I only attempted this using Ye Olde chat interface, not the Agent/MCP insanity everyone is using these days.
If someone else can generate a good visualization of the full tree (including intermediate bits like "ib"), I'll offer a prominent link to a blog or charity of your choice as a bounty.
Brilliant breakdown of the -ib naming hierarchy. The nested structure where -tinib sits under -nib, which then branches into -brutinib, -ertinib, and -metinib really shows how systematic pharma nomenclature has become. What i've noticed in clinicalpractice is that the deeper you go in the hierarchy, the more specific the mechanism but also the narrower the patient population who can benefit. Back when we first got Imatinib, the name was simple and the application was relatively broad for CML, but now with something like Osimertinib targeting EGFR mutations specifically, the precision is incredible but so is the need for biomarker testing.
What is interesting about surveys is if you ask people if they are vegetarian, you get a much higher number than if you ask people if they don't eat any beef, chicken, fish, etc.
I thought it was two women in Chicago:
https://www.latimes.com/business/lazarus/la-fi-lazarus-drug-names-20190719-story.html
Perhaps "tisa" is short for "it is a"
I think "Are you vegetarian" can be seen as either "Are you ethically or religiously opposed to eating meat" or "Is your normal diet meat free" where the latter (but not the former) can be answered "yes" by all the poor Mexicans who would be happy for you to buy them a steak.
Well, Mexico isn't really a poor country. It's a middle-income country:
https://en.wikipedia.org/wiki/List_of_countries_by_GDP_(nominal)_per_capita
However, I think if you asked: (A) "Did you eat meat in the past week" vs. (B) "Are you vegetarian", then broadly speaking, (A) will tend to gather higher numbers than (B) in low-income countries while (B) will tend to gather higher numbers in rich countries. So perhaps there's some kind of interaction between wealth (and wealth distribution) and survey methodology.
Mexico is a middle income country by GDP but GDP is a mean. The median mexican is still poor - $3,315/y according to this:
https://worldpopulationreview.com/country-rankings/median-income-by-country
Even with PPP you're not going to be eating much meat on $3,315/y
Good point! Seems like the Gini Index is also consistent with what you suggest: https://en.wikipedia.org/wiki/Gini_coefficient
Smash X to doubt on the China and Taiwan vegetarian numbers
At least for Taiwan, I think a fair number of people are vegetarian for religious (Buddhism) reasons. And it's generally considered one of the more vegetarian-friendly places to visit. That said, my instinct is that the absolute numbers are on the high side for everywhere except perhaps India.
I can easily believe that there a million of Chinese who cannot afford meat and so are classed as vegetarian. I cannot believe that there are similar numbers of Chinese who don't eat meat for ethical reasons.
Brilliant breakdown of drug naming conventions. The hierarchical suffix system is way more structured than I expected, the PARP inhibitor example with poly ADP-ribose polymerase encoding directly into "parib" is particularly elegant. I've always found it fascinating how pharmaceutical nomenclature tries to balance systematic classification with pronounceability. One thing I noticed working in biotech tho is that these naming patterns sometimes create false associations where drugs with similar suffixes get mentally grouped even when their mechanisms differ significantly in practice.
Spam:
Email spoofing is trivial. Anyone can send an email where the "From:" field says audit@irs.gov, compliance@bigbank.com, donations@localcharity.org or any other address, such as cheap_pills@dynomight.net. Very likely there has been spam spoofed from dynomight.net. Spammers spoof their emails from lots of random real domains. There are extensions to the SMTP protocol to address spoofing, but it's still a problem.
That's why SpamHaus will not believe you right away if you send an email to them where the address in your "From:" is the same tutanota.com address on the About page. Anyone can do that! You need to provide more proof. For example, SpamHaus might ask you to add a property to your dynomight.net DNS record.
That sounds reasonable, and I'd be happy to add a DNS record. But they don't offer any way to do that! After my first attempt my starting line was "I've tried this in the past and you keep closing my tickets with the same generic boilerplate, please tell me exactly what I need to do!" Then they repeat the exact same generic boilerplate and close the ticket, every time.
Unfortunately, SpamHaus has a reputation for exactly the sort of treatment you're getting. To be fair to them, they get huge numbers of SBL removal requests since they want to police the whole Internet, and many are actually maliciously deceptive requests from spammers.
I can only wish you good luck in getting to a human who actually cares about your problem, if the automated systems are barfing on you.
But honestly, if you're not planning on sending any email from dynomight.net, you might consider leaving it blocked to deny its use to actual spammers. In fact, the lack of legitimate emails from the domain is one factor that led to their algorithms blackballing you.
To be clear, it's not just email that's blocked. People cannot access the website!
Oh yes, there are some ISPs that "helpfully" provide a service that blocks malicious websites based on SBL. Ouch. That's painful.
When you communicate with them, are you providing them an email address from tutanota.com, or dynomight.net? If possible, do the latter. You're talking to a rather stupid automated system that has very strict business rules to deal with floods of spammers trying to trick it.
You see, there *is* no email address at dynomight.net. There's no mail server attached, at all. I suppose I could set one up, but going to that much trouble just on a hunch which might or might not lead to a human response which might or might not get me unblocked for the zero spamming I've ever done kind of feels like a violation of my human dignity...
You can alter your dynomight.net DNS MX record to point to your favourite email provider, like tutanota.com. That way, email sent to dynomight.net arrives at tutanota.com, and you can generally set up your account at tutanota.com so you can send from dynomight.net too.
You'll need to check with your email provider and DNS registrar how to do this, but it's not very difficult. You don't have to build an entire email server. You just need to fiddle with some settings at your providers. A few hour project at most, where LLMs can generally give you accurate advice. It should be free, unless your providers are barbaric.
This is still absolute bullshit, I know. Consider it your blood offering to the Internet security gods? You get functioning email at dynomight.net as a bonus at the end? Otherwise you need to get a human at SpamHaus to pay attention.
This is what you're looking for: https://www.who.int/teams/health-product-and-policy-standards/inn/stembook
Including the “Stem Book”, the formal list of all official drug name suffixes, prefixes, and infixes, as well as the “Pre-Stem List” of proposed stems and naming conventions not yet officially adopted.
This is much better than the horrible spreadsheet I found before! But it's not quite what I was hoping for since (1) There's no visualization. (2) It doesn't really explain the tree structure. For example, it doesn't seem to explicitly mention that "-ib" indicates a small molecule inhibitor, even though it surely does. (3) It doesn't explain where the names come from.
>Any nice visualization at all of the entire tree.
Maybe some AI could do a pretty good job of this?
I tried this, but I had a hell of a time even getting it to generate that "-vir" subtree. In order to do that I had to correct lots of mistakes and constantly remind it to follow the exact format I specified, rather than sort or regurgitating the format in existing lists of suffixes. But I only attempted this using Ye Olde chat interface, not the Agent/MCP insanity everyone is using these days.
If someone else can generate a good visualization of the full tree (including intermediate bits like "ib"), I'll offer a prominent link to a blog or charity of your choice as a bounty.
Brilliant breakdown of the -ib naming hierarchy. The nested structure where -tinib sits under -nib, which then branches into -brutinib, -ertinib, and -metinib really shows how systematic pharma nomenclature has become. What i've noticed in clinicalpractice is that the deeper you go in the hierarchy, the more specific the mechanism but also the narrower the patient population who can benefit. Back when we first got Imatinib, the name was simple and the application was relatively broad for CML, but now with something like Osimertinib targeting EGFR mutations specifically, the precision is incredible but so is the need for biomarker testing.
Interesting. So, broadly speaking, a heuristic might be that the longer a drug name, the more specific a patient population it targets?
Did you include Sonic the Hedgehog just to check if humans were reading this?
See also: https://dynomight.net/thanks-4/
I think "lec" in tisagenlecleucel has to do with "sel-lec-tion" of certain cells (just T-cells) from the starting apheresis product (blood).
random story: the rova from rovalptizumab, is for Roanoke, VA, near VA tech where the CEO brian slingerland attended.
I edited that in, thank you!
What is interesting about surveys is if you ask people if they are vegetarian, you get a much higher number than if you ask people if they don't eat any beef, chicken, fish, etc.
My suspicion based on Argentine friends is that they're using "vegetarian" to mean "I skip steak at breakfast on Fridays during lent."
Literally LOLed at this.